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It’s unlikely there’s a difference in absorption rate whether you take butyrate with food or without, although studies are lacking to confirm this one way or the other. There may be a small advantage in taking it with food because that’s when your digestion is really ramped up, releasing digestive enzymes and juices that help you to absorb nutrients. This is a general rule for taking supplements, though, gw50156. It’s not specific to butyrate.
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